Inflammatory bowel diseases, Intestinal wall, integrity, microbes and diet

Genetic identification turns up clues in Inflammatory Bowel Diseases. Extensive epidemiological studies throughout Europe, North America and the UK have uncovered striking findings related to inflammatory bowel diseases, Crohn’s Disease and Ulcerative Colitis. The discovery of two specific genes involved in autophagy (ATG16L1 and IRGM) suggests a role for impaired clearance of intracellular bacteria from GIT epithelial cells in the pathogenesis of Crohn’s Disease. Meanwhile, three new genes have been associated with Ulcerative Colitis which has strong association with intestinal epithelial barrier integrity. These studies are leading to significant changes in the understanding of the pathogenesis of inflammatory bowel diseases.

In Short, intestinal wall integrity has a strong influence in the ability for the bowel to fight unwanted microbes, which cause the inflammatory condition of these diseases.

Blueberries, broccoli and bowel micro flora. Diet is a well-known contributor to the pathogenesis of inflammatory bowel diseases, and phytonutrient-rich foods have been investigated for their role in protecting the gut from inflammation. In an animal model of inflammatory bowel diseases, diets containing either 10% of blueberries or 10% broccoli were shown to reduce levels of certain toxic micro-organisms, whilst increasing butyric acid production in the bowel. These changes collectively improved epithelial barrier integrity and significantly increased goblet cell function in the colon. These findings suggest that blueberries and broccoli contain phytonutrients that can modulate micro flora fermentation and intestinal morphology, helping to improve digestive immunity and reduce colonic inflammation.
For more detailed help with individual cases of inflammatory bowel diseases, please contact our professional Naturopathic Practitioner at:

A Natural Self
A Naturopathy Clinic
Dana Kington
244 South Tce
South Fremantle, 6162

At this natural clinic, you will find all the latest technology, such as Toxicity and Heavy Metal Testing, Live Blood Analysis (Hemaview), and Iridology. We also treat with all forms of Natural Medicine with the nutritional supplementation of Homeopathy, Western Herbs, Chinese medicine, Vitamins, Minerals, Amino acids and Enzyme Therapy.


Heubner C et al. Autophagy Genes in Chrohn’s Disease. 4th Asia Pacific Nutrigenomics Symposium. Feb 2010
Mathew C. The genetics of inflammatory bowel disease. 4th Asia Pacific Nutrigenomics Symposium. Feb 2010.