Antioxidants, Coenzyme Q10, Energy, Fatigue and Ageing

As a potent antioxidant and an integral nutrient for cellular respiration and ATP production, CoQ10 is an extremely valuable nutritional supplement for patients presenting with fatigue, oxidative stress, cardiovascular disease and neurological conditions. As with many supplements, however, the efficacy of CoQ10 supplementation depends largely on prescribing the correct dosage for that patient and understanding the diversity of its mechanisms of action.

CoQ10 is synthesized in the liver from tyrosine via a number of complex chemical reactions, and is concentrated in organs such as the heart, kidneys and muscle.3 This endogenous production naturally declines with age, to the extent where levels may become inadequate for optimal health. According to experimental data, age related reductions in CoQ10 are most evident in the mitochondria (cells that deal with energy production), where the function of the electron transport chain may become affected. It is not surprising then, that elderly patients often present with symptoms of fatigue which could be attenuated with supplemental CoQ10. Moreover, elderly patients commonly suffer from cardiovascular dysfunction and neurological disease which are also associated with CoQ10 depletion.

Among its many biochemical functions, CoQ10 forms an essential part of the cellular machinery responsible for energy production. In the inner mitochondrial membrane, CoQ10 is primarily responsible for the transport of electrons across the protein complexes of the electron transport chain, which ultimately drives ATP production. For this very reason, depleted levels of CoQ10 may impair mitochondrial function and result in symptoms of fatigue and lethargy, which may be attenuated by supplementing with at least 100 mg CoQ10 per day.

For more detailed help with individual cases, call our professional Naturopathic Practitioner:

A Natural Self
A Naturopathy Clinic
Dana Kington
244 South Tce
South Fremantle,